Research Reports - Efficacy of progesterone for moderate to severe traumatic brain injury

Sci Rep. 2015 Aug 25;5:13442. doi: 10.1038/srep13442.

Lin C(1), He H(2), Li Z(1), Liu Y(1), Chao H(1), Ji J(1), Liu N(1).

Progesterone has been shown to have neuroprotective effects in multiple animal
models of brain injury, whereas the efficacy and safety in patients with
traumatic brain injury (TBI) remains contentious. Here, a total of seven
randomized controlled trials (RCTs) with 2492 participants were included to
perform this meta-analysis. Compared with placebo, there was no significant
decrease to be found in the rate of death or vegetative state for patients with
acute TBI (RR = 0.88, 95%CI = 0.70, 1.09, p = 0.24). Furthermore, progesterone
was not associated with good recovery in comparison with placebo (RR = 1.00,
95%CI = 0.88, 1.14, p = 0.95). Together, our study suggested that progesterone
did not improve outcomes over placebo in the treatment of acute TBI.

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