Research Reports - Quality of life in children and adolescents post-TBI: A systematic review and meta-analysis
J Neurotrauma. 2012 Mar 21.
Di Battista A, Soo C, Catroppa C, Anderson V.
BACKGROUND: Traumatic brain injury is (TBI) a leading cause of morbidity and
mortality in children and adolescents in first world nations (Yeates, 2002).
Research from our team investigating adult survivors of pediatric TBI reports
that survivors of severe TBI are particularly vulnerable to global impairments,
including poorer school performance, greater employment difficulties, poor
quality of life (QoL) and increased risk of mental health problems (Anderson,
Brown & Newitt, 2010). Investigation into less observable consequences, including
QoL, has emerged recently as an important outcome to assess in TBI populations.
RATIONALE: The status of QoL in pediatric TBI populations is mixed, likely a
reflection of the varied methodological and theoretical perspectives on QoL. AIM:
This systematic will clarify the nature of QoL in survivors of pediatric TBI, and
to identify predictors of QoL in this group. RESULTS: Of 419 articles identified,
11 studies met our inclusion criteria. 9 were ultimately analyzed in this review.
4 studies reported good QoL and 5 poor QoL. The difference between Good and Poor
QoL was statistically significant due to: TBI severity, Χ2(3) = 77.38, p <0.001 ,
timing of outcome assessment, Χ2(1) = 565,p < 0.001, and definition of QoL, Χ2(3)
= 34.73, p <0.001. The odds of having a poor QoL increased by 5.8 times, RR =
1.21, when injuries were more severe. CONCLUSIONS: Good outcomes are contingent
on milder injuries, proxy reporting and early assessment whereas poor outcomes
reflect more severe injuries and later assessment (≤6 months vs. ≥ 1 year