Research Reports - Traumatic brain injury in individuals at clinical high risk for psychosis
Schizophr Res. 2016 May 7. pii: S0920-9964(16)30192-X. doi:
10.1016/j.schres.2016.04.041. [Epub ahead of print]
Deighton S(1), Buchy L(1), Cadenhead KS(2), Cannon TD(3), Cornblatt BA(4),
McGlashan TH(5), Perkins DO(6), Seidman LJ(7), Tsuang MT(3), Walker EF(8), Woods
SW(5), Bearden CE(9), Mathalon D(10), Addington J(11).
BACKGROUND: Recent research suggests that a traumatic brain injury (TBI) can
significantly increase the risk of later development of psychosis. However, it is
unknown whether people at clinical high risk (CHR) of psychosis have experienced
TBI at higher rates, compared to otherwise healthy individuals. This study
evaluated the prevalence of mild TBI, whether it was related to past trauma and
the relationship of mild TBI to later transition to psychosis.
METHODS: Seven-hundred forty-seven CHR and 278 healthy controls (HC) were
assessed on past history of mild TBI, age at first and last injury, severity of
worst injury and number of injuries using the Traumatic Brain Injury Interview.
Attenuated psychotic symptoms were assessed with the Scale of Psychosis-risk
Symptoms. IQ was estimated using the Wechsler Abbreviated Scale of Intelligence
and past trauma and bullying were recorded using the Childhood Trauma and Abuse
RESULTS: CHR participants experienced a mild TBI more often than the HC group.
CHR participants who had experienced a mild TBI reported greater total trauma and
bullying scores than those who had not, and those who experienced a mild TBI and
later made the transition to psychosis were significantly younger at the age at
first and most recent injury than those who did not.
CONCLUSION: A history of mild TBI is more frequently observed in CHR individuals
than in HC. Inclusion or study of CHR youth with more severe TBI may provide
additional insights on the relationship between TBI and later transition to
psychosis in CHR individuals.