Research Reports - Antioxidant carbon particles improve cerebrovascular dysfunction following traumatic brain injury
ACS Nano. 2012 Sep 25;6(9):8007-14
Bitner BR, Marcano DC, Berlin JM, Fabian RH, Cherian L, Culver JC, Dickinson ME, Robertson CS, Pautler RG, Kent TA, Tour JM
Injury to the neurovasculature is a feature of brain injury and must be addressed
to maximize opportunity for improvement. Cerebrovascular dysfunction, manifested
by reduction in cerebral blood flow (CBF), is a key factor that worsens outcome
after traumatic brain injury (TBI), most notably under conditions of hypotension.
We report here that a new class of antioxidants, poly(ethylene
glycol)-functionalized hydrophilic carbon clusters (PEG-HCCs), which are nontoxic
carbon particles, rapidly restore CBF in a mild TBI/hypotension/resuscitation rat
model when administered during resuscitation-a clinically relevant time point.
Along with restoration of CBF, there is a concomitant normalization of superoxide
and nitric oxide levels. Given the role of poor CBF in determining outcome, this
finding is of major importance for improving patient health under clinically
relevant conditions during resuscitative care, and it has direct implications for
the current TBI/hypotension war-fighter victims in the Afghanistan and Middle
East theaters. The results also have relevancy in other related acute
circumstances such as stroke and organ transplantation.