Research Reports - Corpus callosum integrity and neuropsychological performance after traumatic brain injury

J Head Trauma Rehabil. 2013 Apr 3

Arenth PM, Russell KC, Scanlon JM, Kessler LJ, Ricker JH

OBJECTIVES:: (1) Detailed analysis of diffusion tensor imaging (DTI) parameters
(fractional anisotropy and radial diffusivity) to evaluate white matter integrity
in the corpus callosum (CC), and (2) examine correlations between DTI data and
performance on multiple measures of cognitive functioning. PARTICIPANTS:: Twelve
individuals with a history of complicated mild, moderate, or severe traumatic
brain injury (TBI) who were an average of 1.7 years postinjury and 12 control
participants. MAIN MEASURES:: Standardized and experimental neuropsychological
tests; detailed analysis of DTI parameters. RESULTS:: The TBI group demonstrated
DTI values suggesting decreased white matter integrity and correlations with
severity of injury. Both groups showed correlations between DTI parameters and
cognitive measures, with more significant correlations observed for the TBI
group. White matter changes in the CC were evident chronically and were related
to severity of injury. CONCLUSIONS:: Diffusion tensor imaging parameters
suggesting disruptions in white matter in the CC may be implicated in impaired
performance, both in terms of cognitive tasks and reaction time, after TBI.

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