Research Reports - Interactions between traumatic brain injury and frontotemporal degeneration

Dement Geriatr Cogn Disord. 2015;39(3-4):143-53

Deutsch MB(1), Mendez MF, Teng E

BACKGROUND/AIMS: Prior work in smaller cohorts suggests that traumatic brain
injury (TBI) may be a risk factor for frontotemporal degeneration (FTD). We
sought to confirm and extend these results using the National Alzheimer's
Coordinating Center Uniform Data Set.
METHODS: We compared the TBI prevalence between FTD subjects and matched normal
controls. Indices of cognitive, behavioral, functional, and global dementia
severity were compared between FTD subjects with and without prior TBI.
RESULTS: Remote TBI with extended loss of consciousness (TBI-ext) was more common
in individuals with FTD than in controls (OR: 1.67; 95% CI: 1.004-2.778). With
TBI-ext, less functional and global impairment was seen in the behavioral variant
of FTD, but more behavioral pathology was seen in the semantic variant.
CONCLUSION: TBI may increase the FTD risk and influence clinical symptomatology
and severity in FTD subtypes.

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