Research Reports - Amantadine to treat cognitive dysfunction in traumatic brain injury

Traumatic brain injury (TBI) is a leading cause of injury, disability, and death
in the United States. Amantadine is an established dopamine agonist that supports
neurological function. The purpose of this literature review was to determine
whether amantadine improves cognitive function post-TBI. PubMed and CINAHL were
used to search the literature for articles using amantadine to treat TBI from
1994 to 2004. Outcomes were summarized and the evidence was appraised. Although
earlier studies from 1994 to 2003 were lower-level studies and recommended
further research on treatment of cognitive dysfunction in TBI, the literature
from 2004 to present generally concluded that amantadine improved cognitive
function related to arousal, memory, and aggression. It can be started days to
months postinjury and still produces benefits.

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