Research Reports - Brain recovery after a plane crash: Treatment with growth hormone (GH) and neurorehabilitation

Int J Mol Sci. 2015 Dec 21;16(12):30470-82. doi: 10.3390/ijms161226244.

Devesa J(1,)(2), Díaz-Getino G(3), Rey P(4), García-Cancela J(5), Loures I(6),
Nogueiras S(7), Hurtado de Mendoza A(8), Salgado L(9), González M(10), Pablos
T(11), Devesa P(12).

The aim of this study is to describe the results obtained after growth hormone
(GH) treatment and neurorehabilitation in a young man that suffered a very grave
traumatic brain injury (TBI) after a plane crash.METHODS: Fifteen months after
the accident, the patient was treated with GH, 1 mg/day, at three-month
intervals, followed by one-month resting, together with daily
neurorehabilitation. Blood analysis at admission showed that no pituitary
deficits existed. At admission, the patient presented: spastic tetraplegia,
dysarthria, dysphagia, very severe cognitive deficits and joint deformities.
Computerized tomography scanners (CT-Scans) revealed the practical loss of the
right brain hemisphere and important injuries in the left one. Clinical and blood
analysis assessments were performed every three months for three years. Feet
surgery was needed because of irreducible equinovarus.
RESULTS: Clinical and kinesitherapy assessments revealed a prompt improvement in
cognitive functions, dysarthria and dysphagia disappeared and three years later
the patient was able to live a practically normal life, walking alone and coming
back to his studies. No adverse effects were observed during and after GH
CONCLUSIONS: These results, together with previous results from our group,
indicate that GH treatment is safe and effective for helping neurorehabilitation
in TBI patients, once the acute phase is resolved, regardless of whether or not
they have GH-deficiency (GHD). 

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