Research Reports - Safety of neural stem cell transplantation in patients with severe traumatic brain injury

Exp Ther Med. 2017 Jun;13(6):3613-3618. doi: 10.3892/etm.2017.4423. Epub 2017 May

Wang Z(1), Luo Y(1), Chen L(1), Liang W(1).

Neural stem cell (NSC) therapy is a promising treatment for traumatic brain
injury (TBI). In addition, mesenchymal stem cells (MSCs) have been investigated
for the treatment of TBI due to their functions in neural regeneration and their
neurotrophic effect. In the present study, the safety, feasibility and biological
effects of autologous MSC-derived NSC-like cell transplantation were investigated
in 10 patients with severe TBI. All patients received intravenous or intrathecal
injections of human NSC-like cells and were evaluated with physical and
neurological examinations, routine laboratory tests and neuroradiological
findings. The results indicated that the majority of patients experienced
improved neurological function in different degrees during the follow-up period.
No mortality or serious adverse events were observed in any patient subsequent to
transplantation. Higher serum levels of nerve growth factor and brain-derived
neurotrophic factor were detected following the transplantation, as compared with
the levels prior to treatment. Overall, the present results suggest that
transplantation of autologous NSC-like cells is feasible and appears to be safe
for the treatment of non-acute severe TBI. 

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