Research Reports - Efficacy of methylphenidate for the treatment of mental sequelae after traumatic brain injury

Medicine (Baltimore). 2017 Jun;96(25):e6960. doi: 10.1097/MD.0000000000006960.

Zhang WT(1), Wang YF.

BACKGROUND: This study aimed to evaluate the effect of methylphenidate for
treating mental sequelae after traumatic brain injury (TBI).
METHODS: Thirty-six patients with TBI were randomly divided into the intervention
group and placebo group. The participants in the intervention group received
methylphenidate, while subjects in the placebo group were administered a placebo.
This study was conducted from January 2014 to December 2016. The outcome
measurements included Mental Fatigue Scale, Choice Reaction Time, Compensatory
Tracking Task, Mental Arithmetic Test, Digit Symbol Substitution Test,
Mini-Mental State Examination (MMSE), Beck Depression Inventory (BDI), and
Hamilton Rating Scale for Depression. In addition, safety was also recorded and
assessed.
RESULTS: A total of 33 subjects completed the study. Methylphenidate showed
greater efficacy than placebo, with decreased scores on the Mental Fatigue Scale,
Choice Reaction Time, and Compensatory Tracking Task in the intervention group
compared to the placebo group (P < .01, respectively). Furthermore, increased
scores on the Mental Arithmetic Test, Digit Symbol Substitution Test, and MMSE in
the intervention group, compared to those in the placebo group (P < .01
respectively), were observed. In addition, a significant difference in the scores
on the BDI (P = .04) and Hamilton Rating Scale for Depression (P = .005) was
observed between the 2 groups. The safety at the end of the 30 week-treatment was
similar between the 2 groups (P > .05).
CONCLUSION: The results of this study demonstrated that methylphenidate could
effectively improve mental fatigue and cognitive functions in patients with TBI.
 

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