Research Reports - Neuroimaging changes detected by MEG after low-intensity pulse-based transcranial electrical stimulation

Brain Inj. 2017 Sep 19:1-13. doi: 10.1080/02699052.2017.1363409. [Epub ahead of
print]

Huang MX(1)(2), Swan AR(1)(2), Quinto AA(1)(2), Matthews S(3)(4), Harrington
DL(1)(2), Nichols S(5), Bruder BJ(6), Snook CC(7), Huang CW(8), Baker
DG(1)(9)(10), Lee RR(1)(2).

BACKGROUND: Mild traumatic brain injury (mTBI) is a leading cause of sustained
impairments in military service members, Veterans, and civilians. However, few
treatments are available for mTBI, partially because the mechanism of persistent
mTBI deficits is not fully understood.
METHODS: We used magnetoencephalography (MEG) to investigate neuronal changes in
individuals with mTBI following a passive neurofeedback-based treatment programme
called IASIS. This programme involved applying low-intensity pulses using
transcranial electrical stimulation (LIP-tES) with electroencephalography
monitoring. Study participants included six individuals with mTBI and persistent
post-concussive symptoms (PCS). MEG exams were performed at baseline and
follow-up to evaluate the effect of IASIS on brain functioning.
RESULTS: At the baseline MEG exam, all participants had abnormal slow-waves. In
the follow-up MEG exam, the participants showed significantly reduced abnormal
slow-waves with an average reduction of 53.6 ± 24.6% in slow-wave total score.
The participants also showed significant reduction of PCS scores after IASIS
treatment, with an average reduction of 52.76 ± 26.4% in PCS total score.
CONCLUSIONS: The present study demonstrates, for the first time, the
neuroimaging-based documentation of the effect of LIP-tES treatment on brain
functioning in mTBI. The mechanisms of LIP-tES treatment are discussed, with an
emphasis on LIP-tES's potentiation of the mTBI healing process. 

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