Research Reports - Traumatic brain injury: A risk factor for Alzheimer's disease

Neurosci Biobehav Rev. 2012 May;36(5):1376-81

Sivanandam TM, Thakur MK

Traumatic brain injury (TBI) constitutes a major global health and socio-economic
problem with neurobehavioral sequelae contributing to long-term disability. It
causes brain swelling, axonal injury and hypoxia, disrupts blood brain barrier
function and increases inflammatory responses, oxidative stress,
neurodegeneration and leads to cognitive impairment. Epidemiological studies show
that 30% of patients, who die of TBI, have Aβ plaques which are pathological
features of Alzheimer's disease (AD). Thus TBI acts as an important epigenetic
risk factor for AD. This review focuses on AD related genes which are expressed
during TBI and its relevance to progression of the disease. Such understanding
will help to diagnose the risk of TBI patients to develop AD and design
therapeutic interventions.

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