Research Reports - Association between traumatic brain injury and the subsequent risk of brain cancer

J Neurotrauma. 2012 May 1;29(7):1328-33

Chen YH, Keller JJ, Kang JH, Lin HC

This population-based study in Taiwan aimed to investigate the risk of having a
diagnosis of malignant brain tumors within 3 years after a traumatic brain injury
(TBI). This study used data from the Traumatic Brain Injury Registry and the
National Health Insurance Research Database. The study cohort comprised 5007
patients who had visited ambulatory care centers or had been hospitalized with a
diagnosis of TBI between 2001 and 2002. The comparison cohort was 25,035 randomly
selected enrollees. Each patient's brain cancer status was individually tracked
for a 3-year period following their index date. Stratified Cox proportional
hazards regressions were performed for analyses. During the 3 years of follow-up,
nine patients in each cohort, both the TBI and the non-TBI cohort, were diagnosed
with brain cancer. As compared to those patients without TBI, patients with TBI
were more likely to receive a diagnosis of malignant brain tumors within the
3-year period following their index date: the incidence rate of malignant brain
tumors was 6.28 (95% CI: 3.06-11.53) per 10,000 person-years in patients with TBI
and 1.25 (95% CI: 0.61-2.29) per 10,000 person-years in patients without TBI.
After adjusting for sociodemographic characteristics, the hazard of being
diagnosed with malignant brain tumors during the 3-year follow-up period was 4.67
(95% CI: 1.84-11.83) times greater for those who sustained a TBI than for
patients in the comparison cohort. In addition, we found an association between
TBI severity and malignant brain tumor among patients with TBI (p=0.033). Our
findings suggest a positive correlation between TBI and the relatively short-term
development of malignant neoplasms of the brain.

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