Research Reports - Structural integrity and postconcussion syndrome in mild traumatic brain injury patients

Brain Imaging Behav. 2012 Jun;6(2):283-92

Messé A, Caplain S, Pélégrini-Issac M, Blancho S, Montreuil M, Lévy R, Lehéricy, S, Benali H

The presence of a postconcussion syndrome (PCS) induces substantial
socio-professional troubles in mild traumatic brain injury (mTBI) patients.
Although the exact origin of these disorders is not known, they may be the
consequence of diffuse axonal injury (DAI) impacting structural integrity. In the
present study, we compared structural integrity at the subacute and late stages
after mTBI and in case of PCS, using diffusion-weighted imaging (DWI).
Fifty-three mTBI patients were investigated and compared with 40 healthy
controls. All patients underwent a DWI examination at the subacute (8-21 days)
and late (6 months) phases after injury. MTBI patients with PCS were detected at
the subacute phase using the ICD-10 classification. Groupwise differences in
structural integrity were investigated using Tract-Based Spatial Statistics
(TBSS). A loss of structural integrity was found in mTBI patients at the subacute
phase but partially resolved over time. Moreover, we observed that mTBI patients
with PCS had greater and wider structural impairment than patients without PCS.
These damages persisted over time for PCS patients, while mTBI patients without
PCS partly recovered. In conclusion, our results strengthen the relationship
between structural integrity and PCS.

« Back to Special Reports

Contact Us

We will gladly answer all or your questions about rehabilitation at Centre for Neuro Skills.


phone 1.800.922.4994
or Request a Callback

brain injury store

free brain injury newsletter

why choose cns for brain injury rehabilitation

brain injury newsletter

brain injury store