Research Reports - Diffusion tensor imaging studies of mild traumatic brain injury

J Neurol Neurosurg Psychiatry. 2012 Jul 14

Aoki Y, Inokuchi R, Gunshin M, Yahagi N, Suwa H

ObjectivesTo assess the possibility that diffusion tensor imaging (DTI) can
detect white matter damage in mild traumatic brain injury (mTBI) patients via
systematic review and meta-analysis.MethodsDTI studies that compared mTBI
patients and controls were searched using MEDLINE, Web of Science, and EMBASE,
(1980 through April 2012).ResultsA comprehensive literature search identified 28
DTI studies, of which 13 independent DTI studies of mTBI patients were eligible
for the meta-analysis. Random effect model demonstrated significant fractional
anisotropy (FA) reduction in the corpus callosum (CC) (p=0.023, 95% CIs -0.466 to
-0.035, 280 mTBIs and 244 controls) with no publication bias and minimum
heterogeneity, and a significant increase in mean diffusivity (MD) (p=0.015, 95%
CIs 0.062 to 0.581, 154 mTBIs and 100 controls). Meta-analyses of the subregions
of the CC demonstrated in the splenium FA was significantly reduced (p=0.025, 95%
CIs -0.689 to -0.046) and MD was significantly increased (p=0.013, 95% CIs 0.113
to 0.950). FA was marginally reduced in the midbody (p=0.099, 95% CIs -0.404 to
0.034), and no significant change in FA (p=0.421, 95% CIs -0.537 to 0.224) and MD
(p=0.264, 95% CIs -0.120 to 0.438) in the genu of the CC.ConclusionsOur
meta-analysis revealed the posterior part of the CC was more vulnerable to mTBI
compared with the anterior part, and suggested the potential utility of DTI to
detect white matter damage in the CC of mTBI patients.

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