Research Reports - Are there cognitive and neurobehavioural correlates of hormonal neuroprotection for women After TBI?

Neuropsychol Rehabil. 2013 Jan 30

Niemeier JP, Marwitz JH, Walker WC, Davis LC, Bushnik T, Ripley DL, Ketchum JM

This study examined possible cognitive correlates of hormonal neuroprotection
following traumatic brain injury (TBI) using archival neuropsychological findings
for 1563 individuals undergoing acute TBI rehabilitation between 1989 and 2002.
Presumed age of menopause was based on the STRAW (Stages of Reproductive Aging)
staging system (Soules, 2005; Soules et al., 2001) and general linear model (GLM)
analysis of performance on neuropsychological testing by participants across
gender and age groups (25-34, 35-44, 45-54, and 55-64) was performed. Hypotheses
were (1) women with TBI in the oldest age group would have lower scores on
neuropsychological tests and functional outcome measures than women in the
younger groups, and (2) men in the oldest age group would have higher scores than
women of the same age group. Analyses revealed that oldest females had
significantly worse Trails B and SDMT written and oral scores than the youngest
females. In addition, oldest females had significantly better Trails B, Rey AVLT
and SDMT written scores than the oldest males. Possible cohort exposure to
hormone replacement therapy, unknown hormonal status at time of testing, and
sample-specific injury characteristics may have contributed to these findings.

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