Research Reports - Increased risk of dementia in patients with mild traumatic brain injury: a nationwide cohort study

PLoS One. 2013 May 1;8(5)

Lee YK, Hou SW, Lee CC, Hsu CY, Huang YS, Su YC

BACKGROUND: It is known that the risk of dementia in patients with moderate to
severe traumatic brain injury (TBI) is higher. However, the relationship between
mild traumatic brain injury (mTBI) and dementia has never been established.
OBJECTIVES: We investigated the incidences of dementia among patients with mTBI
in Taiwan to evaluate if there is higher risk compared with general population.
METHODS: We utilized a sampled National Health Insurance (NHI) claims data
containing one million beneficiaries. We followed all adult beneficiaries from
January 1, 2005 till December 31, 2009 to see if they had been diagnosed with
dementia. We further identify patients with mTBI and compared their risk of
dementia with the general population.
RESULTS: We identified 28551 patients with mTBI and 692382 without. After
controlled for age, gender, urbanization level, socioeconomic status, diabetes,
hypertension, coronary artery disease, hyperlipidemia, history of alcohol
intoxication, history of ischemic stroke, history of intracranial hemorrhage and
Charlson Comorbidity Index Score, the adjusted hazard ratio is 3.26 (95%
Confidence interval, 2.69-3.94).
CONCLUSIONS: TBI is an independent significant risk factor of developing dementia
even in the mild type.

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