Research Reports - Head injury and risk of Parkinson disease

Mov Disord. 2013 Aug;28(9):1222-9

Jafari S, Etminan M, Aminzadeh F, Samii A

Head trauma has been implicated in the etiopathogenesis of Parkinson's disease
(PD). We performed a meta-analysis to investigate the association between head
trauma and the risk of developing PD. We included observational studies if they
(1) clearly defined PD, (2) defined head trauma leading to concussion, and (3)
presented odds ratios (ORs) and 95% confidence intervals (CIs) or provided data
to compute these statistics. Random effect model was used to estimate the pooled,
adjusted OR. Heterogeneity between studies was evaluated with the Q test and the
I(2) statistic. We conducted a sensitivity analysis to assess the influence of
each study and repeated the analysis by excluding the studies with the largest
weights. We used funnel plot to assess the presence of publication bias. After
reviewing more than 636 article titles, 34 articles were selected for full
review. In total, 22 studies (19 case-control studies, 2 nested case-control
studies, and 1 cohort study) were included in the meta-analysis. The pooled OR
for the association of PD and head trauma was 1.57 (95% CI, 1.35-1.83). The
results of our meta-analysis indicate that a history of head trauma that results
in concussion is associated with a higher risk of developing PD.

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