Research Reports - Increased levels of interleukin-6, -8 and -10 are associated with fatal outcome following severe traumatic brain injury

Brain Inj. 2014 May 15:1-6

Ferreira LC(1), Regner A, Miotto KD, Moura SD, Ikuta N, Vargas AE, Chies JA, Simon D

Abstract Background: Despite the involvement of cytokine production in
neurotrauma, there is still controversy regarding cytokines levels and clinical
outcome following severe traumatic brain injury (TBI). Objective: The present
study was designed to investigate whether cytokine levels (of IL-1β, IL-6, IL-8,
IL-10, IL-12p70 and TNF-α) are associated with primary outcome (death or
survival) after severe TBI. Methods: This prospective study enrolled 24 male
patients, victims of severe TBI. Venous blood samples were taken in the Intensive
Care Unit (ICU) (study entry), 24 and 48 hours later. Plasma cytokine levels were
assayed by flow cytometry. Results: Severe TBI was associated with a 42%
mortality rate. TBI patients had a significant increase in the levels of all
cytokines measured, except for IL-1β, compared to controls. Statistically
significant increases in the IL-10, -8 and -6 levels were observed in the
non-survivors TBI patients compared to the survivors sub-group measured in the
first sample (study entry) and in the subsequent sample (24 hours later). There
were no significant differences in IL-1β, TNF-α and IL-12p70 levels between
survivors and non-survivors in any time sampled. Conclusions: The findings
indicate that increased IL-10, -8 and -6 levels may constitute an early predictor
of unfavourable outcome in severe TBI patients.

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