Research Reports - Traumatic brain injury in later life increases risk for Parkinson's disease

Ann Neurol. 2015 Feb 27

Gardner RC(1), Burke JF, Nettiksimmons J, Goldman S, Tanner CM, Yaffe K

Objective: Traumatic brain injury (TBI) is thought to be a risk factor for
Parkinson's disease (PD) but results are conflicting. Many studies do not account
for confounding or reverse-causation. We sought to address these concerns by
quantifying risk of PD after TBI compared to non-TBI trauma (NTT, defined as
fractures). Methods: Using inpatient/emergency department (ED) ICD-9 code data
for California hospitals from 2005-2006, we identified patients age ≥55 with TBI
(n=52,393) or NTT (n=113,406) and without baseline PD or dementia who survived
hospitalization. Using Kaplan-Meier estimates and Cox proportional hazards models
(adjusted for age, sex, race/ethnicity, income, comorbidities, healthcare use,
trauma severity), we estimated risk of PD after TBI during follow-up ending in
2011. We also assessed interaction with mechanism of injury (fall vs. non-fall)
and effect of TBI-severity (mild vs. moderate/severe) and TBI-frequency (1 TBI
vs. >1 TBI). Results: TBI patients were significantly more likely to be diagnosed
with PD compared to NTT patients (1.7% versus 1.1%, p<0.001, adjusted hazard
ratio (HR) 1.44, 95% CI 1.31-1.58). Risk of PD was similar for TBI sustained via
falls versus non-falls (interaction p=0.6). Assessment by TBI-severity (mild TBI
HR 1.24, 95% CI 1.04-1.48; moderate/severe TBI HR 1.50, 95% CI 1.35-1.66) and
TBI-frequency (1 TBI HR 1.45, 95% CI 1.30-1.60; >1 TBI HR 1.87, 95% CI 1.58-2.21)
revealed a dose-response. Interpretation: Among patients age ≥55 presenting to
inpatient/ED settings with trauma, TBI is associated with a 44% increased risk of
developing PD over 5-7 years that is unlikely due to confounding or

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