Research Reports - Chronic endocrinopathies in traumatic brain injury disease

J Neurotrauma. 2015 Feb 18

Masel BE(1), Urban R

The aim of this review was to explain the role played by pituitary hormonal
deficiencies in the traumatic brain injury (TBI) disease process. Chronic
dysfunction of the pituitary axis is observed in approximately 35% of individuals
who sustain a moderate-to-severe TBI. The most common deficiency is that of
growth hormone, followed by gonadotropin, cortisol, and thyroid. The medical,
psychological, and psychiatric consequences of untreated hypopituitarism are
extensive and can be devastating. Many of the consequences of a chronic
symptomatic TBI have, in the past, been solely attributed to the brain injury per
se. Analysis of the signs and symptoms of pituitary axis dysfunction suggests
that many of these consequences can be attributed to post-traumatic
hypopituitarism (PTH). PTH may well play a significant role in the progressive
signs and symptoms that follow a chronic TBI.

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