Research Reports - Cognitive functioning in individuals with Parkinson's disease and traumatic brain injury
Parkinsonism Relat Disord. 2016 Sep;30:58-61. doi:
10.1016/j.parkreldis.2016.05.024. Epub 2016 May 24.
Schiehser DM(1), Filoteo JV(2), Litvan I(3), Pirogovsky-Turk E(2), Lessig SL(4),
OBJECTIVE: To examine longitudinal changes in cognition in individuals with
Parkinson's disease (PD) with and without a history of traumatic brain injury
METHODS: Twenty-five PD participants with a history of mild-moderate post-acute
(>9 months) TBI and 25 demographically-matched PD controls without a history of
TBI were administered measures of cognition (Mattis Dementia Rating Scale), mood,
and motor functioning at baseline and at a two-year follow-up evaluation.
RESULTS: Individuals with PD and a history of TBI evidenced significantly greater
decrements in overall cognition over the two year follow-up period compared to
those without a history of TBI. Secondary subscale analyses suggest cognitive
decrements may be mainly in the area of executive function, while a trend for
group differences on the memory subscale was also observed. Groups did not differ
on demographic, motor function, disease severity, cognitive, and mood profiles at
baseline and evidenced comparable changes in mood and motor symptoms from
baseline to follow-up.
CONCLUSION: Findings suggest that a history of mild-moderate TBI is a risk factor
for cognitive decline in individuals with PD.