Research Reports - A prospective analysis of olfactory impairment recovery after severe traumatic brain injury
J Head Trauma Rehabil. 2017 Feb 10. doi: 10.1097/HTR.0000000000000283. [Epub
ahead of print]
Drummond M(1), Douglas J, Olver J.
OBJECTIVE: To investigate the natural progression of olfactory impairment (OI) in
individuals with traumatic brain injury (TBI) at 6 months postinjury.
PARTICIPANTS: Forty-seven adults (mean age = 43.1 years, SD = 18.2), with
predominantly severe TBI (mean posttraumatic amnesia [PTA] duration = 25.5 days,
SD = 22.8).
DESIGN: Consecutive admission longitudinal study.
MAIN MEASURES: Participants were evaluated using the University of Pennsylvania
Smell Identification Test (UPSIT) at resolution of PTA and at 6 months
post-initial injury. Each participant was also interviewed to explore his or her
experience of having an OI. Standard multiple regression was used to assess the
ability of age, PTA duration, presence of facial fractures, and initial UPSIT
score to predict olfactory performance at 6 months.
RESULTS: Thirty-five participants (74%) continued to demonstrate OI at 6 months.
Thirty-two participants (68%) showed some improvement, but only 12 of these
individuals achieved scores within the normal range. The remaining 15
participants either produced a poorer performance (23%) or demonstrated no change
(9%). Initial UPSIT score uniquely accounted for 73.5% of the variance in UPSIT
performance at 6 months.
CONCLUSIONS: Olfactory impairment persists in a substantial proportion of adults
who experience it post-TBI and has the potential to impact a broad spectrum of