Research Reports - Genetic polymorphisms influence recovery from traumatic brain injury

Neuroscientist. 2012 Dec;18(6):631-44

Weaver SM, Chau A, Portelli JN, Grafman J

Traumatic brain injury (TBI) is a major public health concern in both civilian
and military populations. Recently, genetics studies have begun to identify
individual differences in polymorphisms that could affect recovery and outcome of
cognitive and social processes following TBI. This review considers the potential
for polymorphisms to influence six specific cognitive and social functions, which
represent the most prominent domains of impairment following TBI: working memory,
executive function, decision making, inhibition and impulsivity, aggression, and
social and emotional function. Examining the influence of polymorphisms on TBI
outcome has the potential to contribute to an understanding of variations in TBI
outcome, aid in the triaging and treatment of TBI patients, and ultimately lead
to targeted interventions based on genetic profiles.

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