Research Reports - Biopsychosocial outcome following uncomplicated mild traumatic Brain Injury

J Neurotrauma. 2013 Aug 26

Wäljas M, Lange R, Hakulinen U, Huhtala H, Dastidar P, Hartikainen K, Ohman J, Iverson G

The purpose of this study was to examine the biopsychosocial outcome from
uncomplicated mild traumatic brain injury (MTBI) within the first three weeks
post injury. Participants were 48 prospectively enrolled patients from the
Emergency Department of Tampere University Hospital, Finland who sustained an
uncomplicated MTBI. At three weeks post injury, diffusion tensor imaging (DTI) of
the whole brain was undertaken using a Siemens 3T scanner. Measures of fractional
anisotropy (FA) were calculated for 16 regions of interest (ROIs) and measures of
apparent diffusion coefficient (ADC) were calculated for 10 ROIs. Twenty-four
healthy control participants also completed DTI of the whole brain for
comparison. All participants were administered a brief battery of self-report
(e.g., post-concussion symptoms, depression, and fatigue) and neurocognitive
measures (e.g., verbal learning and memory). There were no significant
differences between the uncomplicated MTBI and healthy control group on any
measures of learning and memory. Compared to the control group, the uncomplicated
MTBI group reported a greater number of post-concussion symptoms and fatigue, but
not depression. When considering all DTI ROIs simultaneously, the MTBI group had
a significantly larger number of low DTI measures (FA values) compared to the
healthy controls. MTBI patients with multifocal white matter changes did not show
evidence of worse symptoms, cognitive impairment, or slower return to work
compared to MTBI patients with broadly normal white matter.
 

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