From a treatment standpoint, methods of increasing neuroplasticity can include physical exercise, which has been found to increase neurotrophic factors, a kind of "fertilizer" for the brain, in addition to stimulating angiogenesis. Cognitive exercise can also increase a specific type of "fertilizer" called brain-derived neurotrophic factor (BDNF) and increases synaptogenesis. The question then arises, "What if these therapy activities were combined?" For example, what if you had someone walking on a treadmill while performing some type of cognitive activity so that you stimulate neurotrophic factors on two fronts? One study actually did find that such a combination of activities can exponentially enhance the production of neurotrophic factors.