Research Reports - Neuroendocrine dysfunction and insomniain mild traumatic brain injury patients

Neurosci Lett. 2015 Oct 28;610:154-159. doi: 10.1016/j.neulet.2015.10.055. [Epub
ahead of print]

Zhou D(1), Zhao Y(1), Wan Y(2), Wang Y(2), Xie D(2), Lu Q(2), Yang S(2), Qi X(3).

Mild traumatic brain injury (mTBI) has been a growing public health concern in
the worldwide. To investigate the subjective and objective characteristics of
insomnia following mTBI and the association between insomnia and
hypothalamic-pituitary-adrenal (HPA) function of mTBI patients, 59 patients with
mTBI (mTBI group) were compared with 50 healthy participants (control group) in
the present study. The subjective and objective measures of insomnia were
respectively obtained from Pittsburgh Sleep Quality (PSQI) and polysomnography
(PSG). HPA function was measured with low-dose short synacthen test (LDSST).
According to the comparative and correlation analysis of the two groups, for
PSQI, the scores of sleep syndrome, sleep latency, sleep efficiency, overall
sleep quality and daytime dysfunction of mTBI patients were all higher, however
only sleep efficiency and daytime dysfunction of mTBI patients were related with
peak cortisol on lDSST; while for PSG, sleep efficiency (SE) was lower and wake
after sleep onset (WASO) was longer in mTBI patients, moreover SE and WASO of
mTBI patients were correlated with peak cortisol on LDSTT; for HPA function
indexes, only peak cortisol on LDSST was lower in mTBI patients. These findings
suggested that mTBI patients experienced more serious subjective insomnia
symptoms than objective measurement, which were associated with HPA dysfunction.
This study may contribute to identifying better treatment for mTBI patients with

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