Research Reports - Predictors of depression and posttraumatic stress disorder following traumatic brain injury

J Neuropsychiatry Clin Neurosci. 2017 Feb 14:appineuropsych16090165. doi:
10.1176/appi.neuropsych.16090165. [Epub ahead of print]

Cnossen MC(1), Scholten AC(1), Lingsma HF(1), Synnot A(1), Haagsma J(1),
Steyerberg PE(1), Polinder S(1).

Although major depressive disorder (MDD) and posttraumatic stress disorder (PTSD)
are prevalent after traumatic brain injury (TBI), little is known about which
patients are at risk for developing them. The authors systematically reviewed the
literature on predictors and multivariable models for MDD and PTSD after TBI. The
authors included 26 observational studies. MDD was associated with female gender,
preinjury depression, postinjury unemployment, and lower brain volume, whereas
PTSD was related to shorter posttraumatic amnesia, memory of the traumatic event,
and early posttraumatic symptoms. Risk of bias ratings for most studies were
acceptable, although studies that developed a multivariable model suffered from
methodological shortcomings.

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