Research Reports - Traumatic brain injury and depression in a community-based sample

J Head Trauma Rehabil. 2017 May 17. doi: 10.1097/HTR.0000000000000311. [Epub
ahead of print]

Osborn AJ(1), Mathias JL, Fairweather-Schmidt AK, Anstey KJ.

OBJECTIVES: To determine whether self-reported traumatic brain injuries (TBIs)
are associated with "cases" of clinically significant depression in the general
community. To examine interactions between variables previously linked to
depression after a TBI.
SETTING: Population-based community study (Canberra and Queanbeyan, Australia).
PARTICIPANTS AND DESIGN: Three age cohorts: young, middle-aged, and older adults
(aged 20-24, 40-44, and 60-64 years at baseline) randomly selected from the
electoral roll and followed across 3 waves (4 years apart). A total of 7397,
6621, and 6042 people provided their TBI history in waves 1 to 3.
MEASURES: Lifetime (TBIlifetime: sustained at any time since birth), recent
(TBIrecent: in the preceding 4 years), and multiple (TBImultiple: more than 1)
TBIs, current depression, and known risk factors for depression (age, sex,
marital/employment status, prior history of depression, medical conditions,
recent life events, alcohol consumption, social support, physical activity).
RESULTS: Generalized estimating equations demonstrated a significant association
between sustaining a TBI and experiencing clinically significant depression
(cases), even after controlling for multiple demographic and health/lifestyle
CONCLUSION: There is an enduring association between depression and TBI,
suggesting that, following a TBI, individuals should be monitored and supported
to optimize their long-term psychological health.

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