Research Reports - The impact of traumatic brain injury on later life

J Neurotrauma. 2017 Sep 16. [Epub ahead of print]

Griesbach GS(1)(2), Masel BE(3)(4), Helvie RE(5), Ashley M(6).

The acute and chronic effects of traumatic brain injury (TBI) have been widely
described; however, there is limited knowledge on how a TBI sustained during
early or mid adulthood will influence aging. Epidemiological studies have
explored whether TBI poses a risk for dementia and other neurodegenerative
diseases associated with aging. We will discuss the influence of TBI and
resulting medical comorbidities such as endocrine, sleep and inflammatory
disturbances on age-related grey and white matter changes and cognitive decline..
Post-mortem studies examining amyloid, tau and other proteins will be discussed
within the context of neurodegenerative diseases and chronic traumatic
encephalopathy. The data support the suggestion that pathological changes
triggered by an earlier TBI will have an influence on normal aging processes and
will interact with neurodegenerative disease processes, rather than the
development of a specific disease, such as Alzheimer's or Parkinson's. Chronic
neurophysiologic change after TBI may have detrimental effects on
neurodegenerative disease. 

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