Research Reports - Plasma high-mobility group box 1 levels and prediction of outcome in patients with traumatic brain injury

Clin Chim Acta. 2012 Nov 12;413(21-22):1737-41

Wang KY, Yu GF, Zhang ZY, Huang Q, Dong XQ

BACKGROUND: High-mobility group box 1 (HMGB1), a marker of inflammation, has been
associated with poor outcome of critical illness. The present study was
undertaken to investigate the plasma HMGB1 concentrations in patients with
traumatic brain injury (TBI) and to analyze the correlation of HMGB1 with TBI
METHODS: We performed an observational, clinical study. Plasma HMGB1
concentration of 106 healthy subjects and 106 patients with severe TBI was
measured by ELISA. The correlation with 1-y mortality and unfavorable outcome
(Glasgow Outcome Scale score of 1-3) was analyzed.
RESULTS: Thirty-one patients (29.2%) died and 48 patients (45.3%) had an
unfavorable outcome at 1 y after TBI. Plasma HMGB1 level was substantially higher
in patients than in healthy controls. A multivariate analysis selected plasma
HMGB1 level as an independent predictor for 1-y mortality and unfavorable outcome
of patients. A receiver operating characteristic curve analysis showed plasma
HMGB1 level statistically significantly predicted 1-y mortality and unfavorable
outcome. The prognostic value of HMGB1 was similar to that of Glasgow Coma Scale
score for 1-y clinical outcomes.

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