Research Reports - Biopsychosocial outcome after uncomplicated mild traumatic brain injury

J Neurotrauma. 2014 Jan 1;31(1):108-24

Wäljas M, Lange RT, Hakulinen U, Huhtala H, Dastidar P, Hartikainen K, Ohman J, Iverson GL

Abstract The purpose of this study was to examine the biopsychosocial outcome
from uncomplicated mild traumatic brain injury (MTBI) within the first 3 weeks
post injury. Participants were 48 prospectively enrolled patients from the
Emergency Department of Tampere University Hospital, Finland, who sustained an
uncomplicated MTBI. At 3 weeks post injury, diffusion tensor imaging (DTI) of the
whole brain was undertaken using a Siemens 3T scanner. Measures of fractional
anisotropy (FA) were calculated for 16 regions of interest (ROIs) and measures of
apparent diffusion coefficient (ADC) were calculated for 10 ROIs. Twenty-four
healthy control participants also completed DTI of the whole brain for
comparison. Participants were administered a brief battery of self-report (e.g.,
postconcussion symptoms, depression, and fatigue) and neurocognitive measures
(e.g., verbal learning and memory). There were no significant differences between
the uncomplicated MTBI and healthy control group on any measures of learning and
memory. Compared to the control group, the uncomplicated MTBI group reported a
greater number of postconcussion symptoms and fatigue, but not depression. When
considering all DTI ROIs simultaneously, the MTBI group had a significantly
larger number of low DTI measures (FA values) compared to the healthy controls.
MTBI patients with multifocal white matter changes did not show evidence of worse
symptoms, cognitive impairment, or slower return to work compared to MTBI
patients with broadly normal white matter.

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