Research Reports - Long-term structural changes after mTBI and their relation to post-concussion symptoms

Brain Inj. 2015 Jun 11:1-8

Dean PJ(1), Sato JR, Vieira G, McNamara A, Sterr A

PRIMARY OBJECTIVE: To investigate sustained structural changes in the long-term
(>1 year) after mild traumatic brain injury (mTBI) and their relationship to
ongoing post-concussion syndrome (PCS).
RESEARCH DESIGN: Morphological and structural connectivity magnetic resonance
imaging (MRI) data were acquired from 16 participants with mTBI and nine
participants without previous head injury.
MAIN OUTCOMES AND RESULTS: Participants with mTBI had less prefrontal grey matter
and lower fractional anisotropy (FA) in the anterior corona radiata and internal
capsule. Furthermore, PCS severity was associated with less parietal lobe grey
matter and lower FA in the corpus callosum.
CONCLUSIONS: There is evidence for both white and grey matter damage in
participants with mTBI over 1 year after injury. Furthermore, these structural
changes are greater in those that report more PCS symptoms, suggesting a
neurophysiological basis for these persistent symptoms.

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