Research Reports - Areas of brain damage underlying increased reports of behavioral disinhibition

J Neuropsychiatry Clin Neurosci. 2015 Summer;27(3):193-8

Knutson KM(1), Dal Monte O(1), Schintu S(1), Wassermann EM(1), Raymont V(1),
Grafman J(1), Krueger F(1).

Disinhibition, the inability to inhibit inappropriate behavior, is seen in
frontal-temporal degeneration, Alzheimer's disease, and stroke. Behavioral
disinhibition leads to social and emotional impairments, including impulsive
behavior and disregard for social conventions. The authors investigated the
effects of lesions on behavioral disinhibition measured by the Neuropsychiatric
Inventory in 177 veterans with traumatic brain injuries. The authors performed
voxel-based lesion-symptom mapping using MEDx. Damage in the frontal and temporal
lobes, gyrus rectus, and insula was associated with greater behavioral
disinhibition, providing further evidence of the frontal lobe's involvement in
behavioral inhibition and suggesting that these regions are necessary to inhibit
improper behavior.

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